Key result
Prolonged RV systolic time interval predicts ~17-fold higher risk of severe transient tachypnea in term neonates.
Why the study?
Does an initially prolonged right ventricular systolic time interval predict the development of severe transient tachypnea in term neonates?
Cohort (n=42)
Does an initially prolonged right ventricular systolic time interval predict the development of severe transient tachypnea in term neonates?
Initial measurement of right ventricular systolic time intervals by echocardiography before 4 hours of age strongly predicts the development of severe transient tachypnea in term neonates.
Answers are grounded in this paper and cite their sources.
May warrant early echocardiography for risk stratification in transient tachypnea; leaves open whether RVSTI-guided care improves outcomes.
42 term neonates with transient tachypnea (TTN) underwent echocardiography and determination of systolic time intervals before the age of 4 hours. Based on initial measurement of right ventricular systolic time intervals (RVSTIs) the patients were divided in two groups: neonates with RVSTI ratios less than or equal to 0.50 (Group I) (n = 35) and neonates with RVSTI ratios greater than 0.50 (Group II) (n = 7). Group II neonates also had significantly more prolonged left ventricular systolic time intervals (LVSTIs) than Group I neonates. Group II neonates developed markedly more severe form of TTN than Group I neonates. Initially prolonged RVSTI was best predictor of the development of severe TTN (relative risk ratio 17.5, p less than 0.001): clinical characteristics and oxygen requirements at the admission had limited predictive value.
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Kati Heinonen (1983) conducted a cohort in Transient tachypnea (TTN) (n=42). Right ventricular systolic time interval (RVSTI) ratio > 0.50 vs. RVSTI ratio ≤ 0.50 was evaluated on Development of severe TTN (RR 17.5, p=<0.001). An initially prolonged right ventricular systolic time interval strongly predicted the development of severe transient tachypnea in term neonates.
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