Reports successful hemostatic control using fresh frozen plasma in a laboring patient with severe Factor V deficiency, highlighting effective targeted peripartum management.
Inherited Factor V deficiency is a rare bleeding disorder. We describe the genetic analysis and anesthetic management of a parturient with severe Factor V deficiency who presented in spontaneous labor. Good hemostatic conditions were obtained with prophylactic fresh frozen plasma administration of 10 mL/kg. Detailed genetic analysis by next-generation sequencing identified several relevant mutations in the coding part of the Factor V (F5) gene in our patient, her parents, and the newborn.
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Vaida et al. (2013) studied this question.
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