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Given the burden of growing global health inequities and calls to action for Implementation Science to become more equitable, a renewed approach to advancing knowledge and actions with equity is required. We introduce the Model of Equitable Transdisciplinary Implementation Science (METIS) as a novel response to support the journey of embedding equity, conceptually, methodologically, practically and relationally, at the heart of research, evidence generation, and implementation practice. METIS integrates knowledge systems (Transdisciplinary Science), implementation support systems (Implementation Science), and intrapersonal systems (Relational Theories) with Equity (conceptual, experienced and benchmarked). A theorizing process drives integration to create new equitable knowledge, evidence, practices and relationships which, together, inform the development of equitable implementation strategies and outcomes. METIS components are presented alongside an example of an Australian First Nations Framework reflecting alignment and providing an option for Implementation Science researchers and practitioners to utilize a model that is grounded in pluralistic epistemologies, relationality and context to provide real-world solutions to real-world challenges. A case study applying METIS to inform the development of an early parenting outcomes framework and its implementation plan is also outlined, as are recommendations for future research and evaluation.
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O'Connor et al. (2026) studied this question.