N‐Trifluoromethylthiosaccharin: An Easily Accessible, Shelf‐Stable, Broadly Applicable Trifluoromethylthiolating Reagent

A new, electrophilic trifluoromethylthiolating reagent, N‐trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N‐trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron‐rich arenes, aldehydes, ketones, acyclic β‐ketoesters, and alkynes under mild reaction conditions.