Key result
Sequencing wild type poliovirus in India reveals endemic circulation and wide genetic variation across genotypes.
Observational (n=70)
The study demonstrates the endemic circulation and wide genetic variation of all three poliovirus serotypes in Southern India prior to National Immunization Days.
Establishes pre-NID poliovirus genotype baseline in India; leaves open needs for ongoing genomic surveillance in eradication programs.
In order to study the genetic relationships and epidemiological links between strains circulating in the Vellore region of India, 70 wild type poliovirus strains isolated from paralytic poliomyelitis cases were sequenced at the VP1-2A junction region of the viral genome. This showed that three genotypes of types 1 and 2 and four genotypes of type 3 poliovirus were circulating in India at least since 1985. Different clusters were identified within wild genotypes. This study demonstrates the endemic circulation and wide genetic variation of all three serotypes in Southern India. Knowledge of wild poliovirus distribution before NIDs beginning could be helpful for a critical monitoring of poliomyelitis control and further evaluation of the NIDs impact on wild poliovirus transmission in India.
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Dahourou et al. (2010) conducted an observational in Paralytic poliomyelitis (n=70). Wild type poliovirus strains was evaluated on Genetic relationships and epidemiological links (genotypes). Sequencing of 70 wild type poliovirus strains from paralytic poliomyelitis cases in India revealed endemic circulation and wide genetic variation of three genotypes of types 1 and 2 and four of type 3.
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