Key result
Adjunctive CoQ10 may improve cardiac output, NYHA class, and survival in congestive heart failure.
Why the study?
Does Coenzyme Q10 supplementation improve clinical and functional outcomes in patients with heart failure?
Systematic Review (n=7)
Does Coenzyme Q10 supplementation improve clinical and functional outcomes in patients with heart failure?
Coenzyme Q10 supplementation may serve as a useful adjunctive therapy in heart failure management, particularly for patients who cannot tolerate standard medical therapies.
Answers are grounded in this paper and cite their sources.
Supports adjunctive CoQ10 consideration in HF patients intolerant to standard therapy; extends cumulative systematic review evidence.
INTRODUCTION: This article is an attempt to provide an overview of systematic reviews to determine the efficacy of CQ10 supplementation in the treatment of patients with cardiovascular diseases (CVD). METHOD AND MATERIAL: All reviews were identified through a systematic search of the following databases: Cochrane, DARE, Ovid, EMBASE, ISI Web of Knowledge, and PubMed. Check references studies and the quality of the studies was assessed by means of AMSTTAR. No meta-analyses were performed due to the heterogeneity of studies. RESULT: Extracted data for Seven systematic reviews for primary outcomes, net changes in cardiac output, cardiac index, New York Heart Association functional classification, improved survival, based on existing evidence, there is a case for use of CoQ10 as an adjunctive therapy in congestive heart failure, especially in those patients unable to tolerate mainstream medical therapies. CONCLUSION: Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.
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Jafarı et al. (2018) conducted a systematic review in Heart failure (n=7). Coenzyme Q10 (CQ10) supplementation was evaluated on Net changes in cardiac output, cardiac index, New York Heart Association functional classification, and improved survival. Based on 7 systematic reviews, Coenzyme Q10 supplementation may be a useful adjunctive therapy for managing patients with congestive heart failure.
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