CYP1A1 * 2B and * 4 Polymorphisms are associated with Lung Cancer Susceptibility in Mexican Patients

Background CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk. More specifically, CYP1A1 * 2B and * 4 polymorphisms have been associated with high susceptibility to lung cancer among cigarette smokers. Materials and methods: DNA was obtained from blood samples and we studied by PCR-RFLP the distribution of CYP1A1 * 2B (n=248) and * 4 (n=222) polymorphisms in healthy controls and 222 lung cancer patients from a Mexican population. Results Comparisons between groups showed an increased risk for lung cancer patients of * 2B/ * 2B (18%; OR 7.6; 95% CI 3.0–19.2) and * 4/ * 4 genotypes (15%; OR 11.45; 95% CI 2.19–59.85) compared to the control group (1% for * 2B/ * 2B and 4.4% for * 4/ * 4). A significant association between lung cancer and homozygous * 2B/ * 2B passive smokers and * 4/ * 4 ever (cigarettes) and passive smokers was also observed (p<0.05). Multivariate analysis revealed an increased risk for the * 2B/2B genotype (OR 6.83), as well as for * 4/ * 4 (OR 28.8). Conclusion The results of the study indicate a significant association between * 2B/ * 2B and * 4/ * 4 genotypes and the risk of developing lung cancer among Mexicans.