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August 1, 2016Ars medica tomitanaOpen Access

Carotid Artery Disease - Left vs Right

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Key result

Carotid plaques linked to ~296% greater ischemic stroke risk versus no plaques.

  • P=0.024
  • n=159

Why the study?

Does the presence and specific location of carotid atherosclerotic plaques correlate with the occurrence of ischemic stroke in patients with carotid atherosclerosis?

Population

159 patients with carotid atherosclerosis. Excluded: other causes of cerebral ischemia and transient…

Comparison

Presence and specific location of carotid… vs Absence of plaques or alternative plaque locations

Design

Cross-sectional

Authors

AIAna-Maria IonescuOvidius UniversityNCN. CârciumaruOvidius UniversitySCSergiu ChirilăOvidius University

Discussion

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Implication

May link carotid atherosclerosis to first ischemic stroke in this cohort; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Observational (n=159)

Structured PICO

Does the presence and specific location of carotid atherosclerotic plaques correlate with the occurrence of ischemic stroke in patients with carotid atherosclerosis?

P
Population
159 patients with carotid atherosclerosis, excluding those with other causes of cerebral ischemia, evaluated for the association between carotid plaques and ischemic stroke.
E
Exposure
Presence and specific location (left vs right, pre-bulbar, bulbar, internal carotid artery) of carotid atherosclerotic plaques assessed by ultrasound
C
Comparator
Absence of plaques or alternative plaque locations
O
Outcome
Occurrence of first ischemic large arterial strokehard clinical

Main Result

Absolute Event Rate: 22.6% vs 5.7%

p-value: p=0.024

Atherosclerotic plaques located at the internal carotid artery, particularly on the left side, are significantly associated with the occurrence of ischemic stroke.

Cite This Study

Ionescu et al. (2016) conducted an observational in Carotid atherosclerosis (n=159). Carotid plaques vs. Absence of carotid plaques was evaluated on Occurrence of ischemic stroke (p=0.024). The presence of carotid plaques was significantly associated with a higher occurrence of ischemic stroke compared to patients without plaques (22.6% vs 5.7%, p=0.024).

synapsesocial.com/papers/6aa16ae9dc6fbdec443d4df8https://doi.org/10.1515/arsm-2016-0028
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bilateral Symmetry of Human Carotid Artery Atherosclerosis2002 · 66 citations
  2. 2Carotid Artery Anatomy and Geometry as Risk Factors for Carotid Atherosclerotic Disease2012 · 148 citations
  3. 3Is Carotid Stenosis in Women a Gender-Related Condition?2015 · 7 citations
  4. 4In Vivo Association Between Low Wall Shear Stress and Plaque in Subjects With Asymmetrical Carotid Atherosclerosis1997 · 257 citations
  5. 5Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.1993 · 12,485 citations