Key result
Higher monocyte-to-HDL ratio is linked to contrast-induced nephropathy after primary PCI in STEMI.
Why the study?
Contrast-induced nephropathy is linked to higher morbidity and mortality after primary PCI, and the study aimed to explore the correlation between monocyte to HDL ratio and CIN in patients presenting with STEMI.
Does the monocyte to high-density lipoprotein ratio predict contrast-induced nephropathy in STEMI patients treated with primary PCI?
Observational (n=80)
Does the monocyte to high-density lipoprotein ratio predict contrast-induced nephropathy in STEMI patients treated with primary PCI?
Absolute Event Rate: 0.0202% vs 0.0129%
p-value: p=0.003
An elevated monocyte to high-density lipoprotein ratio (>0.0131) may serve as a useful predictive biomarker for contrast-induced nephropathy in STEMI patients undergoing primary PCI.
Background: Following primary percutaneous coronary intervention (PCI), contrast-induced nephropathy (CIN) is linked to higher mortality and morbidity. The monocyte to high density lipoprotein cholesterol ratio (MHR), which has been used as a novel predictive marker in patients with cardiovascular and renal disorders, has been linked in several studies to a number of negative cardiovascular outcomes. Objective: The current study was conducted to explore correlation between monocyte to HDL ratio and CIN after primary PCI in patients presented with ST-segment Elevation Myocardial Infarction (STEMI). Patients and methods: A total of 80 patients with acute STEMI were included. Patients were differentiated into two groups according to development of contrast induced nephropathy; Group (A) Patients who developed contrast induced nephropathy, and Group (B) Patients did not develop contrast induced nephropathy. CIN was defined as either a 25% increase in serum creatinine from baseline or 0.5 mg/dL increase in absolute value, within 48-72 h of intravenous administration of contrast medium. Results: A total of 16 (20%) patients developed CIN. MHR was significantly higher in CIN positive group [mean 0.0202 (range 0.009-0.0633) 108/mg] than non-CIN group [mean 0.0129 (range 0.0031-0.0307) 108/mg] with P-value = 0.003. MHR was also significantly correlated with creatinine levels 48 hours after PCI (rs: 0.322, P: 0.004). ROC statistical analysis showed that MHR >0.0131 was the best cutoff values for predicting contrast induced nephropathy with sensitivity 76% and specificity 71.2%. Conclusion: Higher MHR levels may predict CIN development after primary PCI in STEMIpatients.
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Emara et al. (2023) conducted an observational in ST-segment Elevation Myocardial Infarction (STEMI) (n=80). Monocyte to high-density lipoprotein cholesterol ratio (MHR) vs. Lower MHR was evaluated on Contrast-induced nephropathy (CIN) (p=0.003). Higher monocyte to HDL ratio was significantly associated with the development of contrast-induced nephropathy after primary PCI in STEMI patients (mean 0.0202 vs 0.0129; P=0.003).
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