Synthesis of Some New Pyridine-2,6-bis-heterocycles

The versatile multifunctional hitherto unreported pyridine-2,6bis[ethyl 2-(N,N-dimethylamino)methylene-3-oxopropanoate] (2) was prepared by the reaction of pyridine-2,6-bis(ethyl 3-oxopropanoate) (1) with 1,1dimethoxytrimethylamine.Several new pyrazole, isoxazole, pyrimidine, pyrazolo[1,5-a]pyrimidine, and imidazo[1,2-a]pyrimidine derivatives attached to pyridine ring at 2,6-positions have been synthesized by the reactions of the enaminone 2 with the appropriate nitrogen binucleophiles.