Key result
As the zebrafish heart develops from 3 to 6 days post-fertilization, the maximum shear rate at the ventricular-bulbar valve reduces from approximately 440 s-1 to 180 s-1.
Absolute Event Rate: 440% vs 180%
A novel imaging and velocimetry methodology enables accurate in vivo measurement of wall shear stress in the developing zebrafish heart, demonstrating that shear forces decrease and become more uniform as the heart matures.
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Advances zebrafish shear quantification in vivo; extends developmental tools while leaving mammalian translation open.
Jamison et al. (2013) studied Embryonic heart development (n=16). In vivo wall shear measurement methodology was evaluated on Maximum wall shear rate at the ventricular-bulbar valve. As the zebrafish heart develops from 3 to 6 days post-fertilization, the maximum shear rate at the ventricular-bulbar valve reduces from approximately 440 s-1 to 180 s-1.
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