Key result
BCG-M vaccine is linked to fewer post-vaccination complications than standard BCG in children.
Why the study?
BCG strains have residual virulence and can cause post-vaccination complications, prompting a comparison of complications between BCG and BCG-M vaccination in children.
Does BCG-M vaccine reduce post-vaccination complications compared to BCG vaccine in children?
Cohort (n=557)
Does BCG-M vaccine reduce post-vaccination complications compared to BCG vaccine in children?
BCG-M vaccine is associated with fewer post-vaccination complications than standard BCG in children, suggesting a safer profile especially in those with altered immunological reactivity.
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Chernyak et al. (2019) conducted a cohort in Tuberculosis vaccination (n=557). BCG-M vaccine vs. BCG vaccine was evaluated on Frequency and structure of post-vaccination complications. The use of BCG-M vaccine reduced the frequency and proportion of post-vaccination complications compared to standard BCG vaccination in children.
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