Key result
LRA cuts fluoroscopy time ~17% and lowers contrast volume vs RRA in diabetic patients.
Why the study?
Does the left radial approach reduce contrast volume and fluoroscopy time compared to the right radial approach in diabetic patients undergoing coronary procedures?
RCT (n=512)
Randomized to LRA or RRA
No
Does the left radial approach reduce contrast volume and fluoroscopy time compared to the right radial approach in diabetic patients undergoing coronary procedures?
Absolute Event Rate: 143% vs 172%
p-value: p=0.005
In diabetic patients undergoing coronary procedures, the left radial approach significantly reduces fluoroscopy time and contrast volume compared to the right radial approach.
LRA cuts fluoroscopy time and contrast versus RRA for CAG in diabetics; extends RCT data favoring left radial access in this group.
Background: Radial arterial approach is the usual option for coronary procedures in our hospital. Our aim was to evaluate the safety and efficacy of left radial approach (LRA) compared with right radial approach (RRA) for coronary procedures.Methods: This study is a single centre, single operator randomized study. Only diabetic patients more than 18 years old with bilateral normal allens test requiring coronary procedures (CAG and PCI) were included in this study. Study period was since January, 2011 to February, 2012. Primary PCI were excluded from this study. The patients were randomized to LRA or RRA arm for coronary procedures. Primary endpoint for diagnostic CAG was contrast volume and fluroscopy time and secondary endpoint was the prevalence of high grade subclavian tortuosity and number of diagnostic catheters used. Size of the conventional guide catheter (5 or 6 F) was compared in both arms irrespective of left or right coronary PCI.Results: Total 512 diabetic patients were enrolled for CAG and equally divided into LRA (256 patients) or RRA (256 patients) arms. Total 290 PCI was performed (145 LRA and 145 RRA). In CAG, LRA arm showed significantly lower fluroscopy time (p = 0.006) and contrast volume (p= 0.005) though more use of double diagnostic catheter (5 F TIG and JR) was present in LRA group. In PCI, RRA arm needed signicantly more 5 F guide catheter (p=0.001). Subclavian tortuosity were more observed in female RRA group.Conclusions: In diabetic population, CAG by left radial approach was superior to right in terms of amount of contrast and fluroscopy time. Subclavian tortuousity was more observed in right and especially more in female. In PCI, 6 F conventional guide catheters were commonly used in both approache though 5 F guide catheter were used more in right radial approach due to extreme subclavian tortuousity and diffuse disease. Dedicated sheathless guide catheter may resolve this issue.University Heart Journal Vol. 11, No. 1, January 2015; 26-29
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Khan et al. (2016) conducted an RCT in Coronary artery disease requiring coronary procedures in diabetic patients (n=512). Left radial approach (LRA) vs. Right radial approach (RRA) was evaluated on Fluoroscopy time (seconds) during diagnostic coronary angiography (p=0.005). The left radial approach significantly reduced fluoroscopy time (143 vs 172 seconds, p=0.005) and contrast volume (37 vs 47 mL, p=0.006) compared to the right radial approach in diabetic patients.
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