Key result
Intramuscular gamma globulin yields transient Lansing virus neutralizing antibodies while oral administration produces none.
Why the study?
Does intramuscular or oral gamma globulin administration produce detectable Lansing virus neutralizing antibody in humans?
Does intramuscular or oral gamma globulin administration produce detectable Lansing virus neutralizing antibody in humans?
Intramuscular, but not oral, administration of gamma globulin provides temporary, low-level passive immunity against Lansing poliomyelitis virus in humans.
IM gamma globulin may confer transient passive immunity; leaves open clinical efficacy and optimal regimens for poliomyelitis prevention.
The sera of 51 children and over 300 adults were first tested for the presence of Lansing virus neutralizing antibody. 2. Of those whose serum contained no demonstrable antibody, 6 children and 4 adults were given gamma globulin intramuscularly in doses from 0.1 to 0.4 ml per pound body weight. 3. Blood was taken at frequent intervals for 6 weeks and tested for antibody. A small quantity of antibody was present in the serum, as shown by a protective effect of the undiluted sample in mice. This antibody was detected in some cases for a few weeks. 4. No antibody was found in the serum of the same 10 persons following the oral administration of gamma globulin.
No takes yet. Share an insight, caveat, or question.
Wood et al. (1952) studied Poliomyelitis (n=10). Intramuscular gamma globulin vs. Oral gamma globulin was evaluated on Presence of Lansing virus neutralizing antibody in serum. Intramuscular administration of gamma globulin resulted in a small, transient quantity of Lansing virus neutralizing antibody in the serum, whereas oral administration produced no detectable antibody.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: