Key result
Verapamil therapy produced a consistent reduction in 24-hour ambulatory blood pressure and heart rate compared to no therapy, without causing postural hypotension.
Why the study?
Does verapamil reduce ambulatory blood pressure in patients with hypertension?
Does verapamil reduce ambulatory blood pressure in patients with hypertension?
Verapamil effectively reduces ambulatory blood pressure and heart rate over 24 hours in hypertensive patients.
Answers are grounded in this paper and cite their sources.
Supports verapamil for ambulatory BP control without orthostasis; hypothesis-generating pending randomized outcome trials.
The 'Oxford' system for continuous monitoring of the ambulatory blood pressure was used to assess the changes in blood pressure following therapy with the slow channel inhibitor, verapamil. Sixteen patients were studied on no therapy and following a minimum of 6 weeks therapy (dose range 120-160 mg t.d.s.). During each study patients underwent standardized physiological tests including tilt, isometric handgrip and dynamic bicycle exercise. Verapamil was demonstrated to produce a consistent reduction of blood pressure over most of the 24 h period studied but this was most marked during the day. Heart rate was also reduced. There was no postural hypotension and the absolute responses to dynamic and isometric exercise were reduced. The results demonstrate the antihypertensive efficacy of 'slow channel inhibitors' as represented by verapamil.
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Gould et al. (1984) studied Hypertension (n=16). Verapamil vs. no therapy was evaluated on changes in blood pressure. Verapamil therapy produced a consistent reduction in 24-hour ambulatory blood pressure and heart rate compared to no therapy, without causing postural hypotension.
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