Key result
Intravenous diltiazem slightly reduced coronary flow reserve from 3.9 to 3.6 (p<0.01), whereas intracoronary diltiazem left it unchanged at 3.8, preserving its diagnostic validity.
Why the study?
Does diltiazem reduce coronary flow reserve in awake humans?
Population
Awake humans undergoing coronary flow reserve measurement
Comparison
Diltiazem administered by intravenous or… vs Baseline measurements prior to diltiazem…
Design
Other
Follow-up
Immediate (during procedure)
Authors
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Diltiazem does not meaningfully attenuate maximal coronary dilation or invalidate coronary flow reserve measurements for diagnostic purposes.
Does diltiazem reduce coronary flow reserve in awake humans?
Absolute Event Rate: 3.6% vs 3.9%
p-value: p=<0.01
Diltiazem does not meaningfully attenuate maximal coronary dilation or invalidate coronary flow reserve measurements for diagnostic purposes.
Rossen et al. (1989) studied this question. Diltiazem vs. Baseline was evaluated on Coronary flow reserve (peak-to-resting flow velocity ratio) after intravenous diltiazem (p=<0.01). Intravenous diltiazem slightly reduced coronary flow reserve from 3.9 to 3.6 (p<0.01), whereas intracoronary diltiazem left it unchanged at 3.8, preserving its diagnostic validity.
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