Key result
Persistent and remitted NSSI are linked to ~42% lower suicide reattempt risk versus no NSSI.
Why the study?
Non-suicidal self-injury in adults after a suicide attempt may follow distinct courses with different clinical profiles and reattempt risk.
Do different patterns of non-suicidal self-injury (NSSI) affect the risk of suicide reattempts over 12 months in adults after an index suicide attempt?
Cohort (n=685)
Do different patterns of non-suicidal self-injury (NSSI) affect the risk of suicide reattempts over 12 months in adults after an index suicide attempt?
Hazard Ratio: 0.58 (95% CI 0.35–0.96)
While NSSI persistence signals elevated clinical risk, it is associated with a reduced 12-month hazard of suicide reattempt compared to no NSSI, possibly due to short-term affect regulation.
May not signal elevated short-term reattempt risk post-index attempt; leaves open mechanisms and prospective validation needs.
BACKGROUND: Non-suicidal self-injury (NSSI) in adults after a suicide attempt may follow distinct courses with different clinical profiles and reattempt risk. AIMS: Examine NSSI patterns, correlates, and associations with suicide reattempts over 12 months. METHOD: Adults (n = 685; 72.4% female; mean age 42 [SD 15.45]) were assessed ≤15 days post-index attempt and followed 12 months. NSSI was assessed using Columbia-Suicide Severity Rating Scale (C-SSRS). Baseline assessments captured psychiatric diagnoses, global psychological distress, impulsivity, fearlessness about death, and childhood trauma (assessed with the MINI, BSI, BIS-11, ACSS-FAD, and CTQ-SF, respectively), and suicide-related variables; reattempts were tracked throughout follow-up. RESULTS: Four a priori patterns: NN (No NSSI→No NSSI; 53.4%), Onset (No→Yes; 5.7%), Remission (Yes→No; 23.9%), and Persistence (Yes→Yes; 16.9%). Persistence was associated with younger age and higher baseline impulsivity, higher baseline global psychological severity, and greater childhood trauma severity along with substance use before the attempt and higher acquired capability. PTSD predicted reattempt within Persistence. Onset was linked to earlier reattempts, narrowing the intervention window, whereas Persistence showed a modest descriptive delay, consistent with short-term regulation (without implying protection). During follow-up, 22.2% reattempted; median time-to-reattempt 138 days (IQR 55-222; mean 149). In multivariable Cox regression, older age showed lower hazard (HR 0.98, 95% CI 0.96-0.99), and a greater number of prior suicide attempts (HR 1.02, 1.01-1.04). Relative to NN, Remission (HR 0.56, 0.32-0.96) and Persistence (HR 0.58, 0.35-0.96) were associated with reduced 12-month hazard. CONCLUSIONS: While NSSI may briefly down-regulate severe affect, Persistence signals elevated clinical risk and acquired capability; Onset appears linked to earlier reattempts.
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Arqueros et al. (2026) conducted a cohort in Suicide attempt (n=685). Persistent non-suicidal self-injury (NSSI) vs. No NSSI was evaluated on Suicide reattempt (HR 0.58, 95% CI 0.35-0.96). Relative to no non-suicidal self-injury, both persistent (HR 0.58; 95% CI 0.35-0.96) and remitted NSSI (HR 0.56; 95% CI 0.32-0.96) were associated with a reduced 12-month hazard of suicide reattempt.
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