A Practical Approach to Prosthetic Valve Endocarditis

Prosthetic valve endocarditis (PVE) is an infrequent but dread complication, occurring in 1 to 2% of patients both early (less than 60 days) and late postoperatively.Diagnosis is always (99%) possible by two sets of blood cultures, but occasional exogenous causes of bacteremia may cloud the diagnosis, as will culture-negative cases of PVE and skin contaminants.With obvious exogenous sources of bacteremia, achieving sterile blood cultures after eradication of the noncardiac source permits discontinuation of antibiotics after two weeks.When skin contaminants are suspected, withholding antibiotics and obtaining two sets of blood cultures is recommended, because the bacteremia with PVE is continuous.Preventive measures, including perioperative antibiotics, are warranted but will probably not significantly reduce the low incidence of infection already achieved.The major cause of improved survival in recent years is earlier operation (valve rereplacement).This has been demonstrated in the last ten years and is absolutely indicated for major heart failure, ongoing sepsis, fungous etiology, valve obstruction, new-onset heart block, and unstable prosthesis by fluoroscopy.Prosthetic valve endocarditis (PVE) is one of the most serious complications in cardiac surgery.Mortality commonly exceeds 50%, yet the inevitably limited number of patients in each series has hampered guidelines for prevention, diagnosis, and therapy.The purpose of this review is to collate the available information on PVE and propose a practical, clinical approach to this dreaded disease.