Apparent Potentiation by Phenobarbital of Hepatotoxicity from Small Doses of Acetaminophen

Letters and Corrections1 September 1984Apparent Potentiation by Phenobarbital of Hepatotoxicity from Small Doses of AcetaminophenJEAN H. PIROTTE, M.D.JEAN H. PIROTTE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-403_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Acute hepatic necrosis is characteristically associated with single large overdoses of acetaminophen (paracetamol) ingested with suicidal intent. However, occasional reports have suggested that the continued administration of therapeutic doses may result in hepatic damage (1-5). We describe an additional case of hepatitis related to small doses of acetaminophen, the toxicity of which was apparently potentiated by the concomitant ingestion of phenobarbital.An epileptic 48-year-old woman who was being treated with phenobarbital (100 mg/d) was examined because of generalized discomfort and weakness. She had been taking acetaminophen (1 g/d) for headaches for 3 months.Her liver was palpable...References1. BARKERDE CARLEANURAS JDS. Chronic excessive acetaminophen use and liver damage. Ann Intern Med. 1977;87:299-301. LinkGoogle Scholar2. JOHNSONTOLMAN GK. Chronic liver disease and acetaminophen. Ann Intern Med. 1977;87:302-4. LinkGoogle Scholar3. SACHERTHALER MH. Toxic hepatitis after therapeutic doses of benorylate and D-penicillamine. Lancet. 1977;1:481-2. CrossrefMedlineGoogle Scholar4. BONKOWSKIMUDGEMCMURTRY HGR. Chronic hepatic inflammation and fibrosis due to low doses of paracetamol. Lancet. 1975;1:1016-8. MedlineGoogle Scholar5. LICHTSEEFFZIMMERMAN HLH. Apparent potentiation of acetaminophen hepatotoxicity by alcohol. Ann Intern Med. 1980;92:511. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital de Bavière Institut de Médicine Universitaire de Liège B-4020 Liège Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNon-Intensive Care Unit Management of Acute and Acute on Chronic Liver FailureDrug-Induced Liver InjuryPharmGKB summaryAcetaminophenMathematical modeling of liver injury and dysfunction after acetaminophen overdose: Early discrimination between survival and deathMicroscale culture of human liver cells for drug developmentDoes Therapeutic Use of Acetaminophen Cause Acute Liver Failure?Genomic Profiling in Nuclear Receptor-Mediated ToxicityEstimates of acetaminophen (paracetomal)-associated overdoses in the United StatesKinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen−Induced HepatotoxicityPhenobarbital and Phenytoin Increased Acetaminophen Hepatotoxicity Due to Inhibition of UDP-Glucuronosyltransferases in Cultured Human HepatocytesHépatite fulminante après une dose thérapeutique de paracétamol chez un alcoolique chroniqueModulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CARChronic acetaminophen toxicity: a case report and review of the literatureAlcohol exposure and paracetamol-induced hepatotoxicityOsteoarthritis IV: Clinical therapeutic trials and treatmentMetabolic AntidotesChronic acetaminophen overdosing in children: risk assessment and managementParacetamol, alcohol and the liverACETAMINOPHEN HEPATOTOXICITYDrug interactions and the clinical anaesthetistHEPATOTOXICITY OF ANALGESICS AND ANTI-INFLAMMATORY AGENTSA review of the hepatotoxicity of paracetamol at therapeutic or near-therapeutic dose levels, with particular reference to alcohol abusersLong-Term Anticonvulsant Therapy Worsens Outcome in Paracetamol-Induced Fulminant Hepatic FailureUse of N-acetylcysteine in clinical toxicologyPrediction of organ system toxicity with antirheumatic drug therapyAcetaminophen Chronic ToxicityDrug Interactions and Adverse Reactions 1 September 1984Volume 101, Issue 3Page: 403-403KeywordsHepatitisIngestionLiverNecrosisToxicity Issue Published: 1 September 1984 PDF DownloadLoading ...