Key result
A diet rich in linoleic acid increased contractile force, coronary flow rate, and prostaglandin release, while diminishing the inotropic effects of isoprenaline in isolated rat hearts.
Why the study?
Does a diet rich in linoleic acid alter cardiac function, prostaglandin release, and the response to isoprenaline in isolated rat hearts?
Population
Male Wistar rats (isolated rat heart preparations)
Comparison
Diet rich in linoleic acid for up to 10 weeks vs LA-deficient diet and standard lab chow
Design
Preclinical
Follow-up
10 weeks
Authors
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Alters cardiac performance in rats; leaves open relevance to human diets or beta-adrenergic therapies.
Does a diet rich in linoleic acid alter cardiac function, prostaglandin release, and the response to isoprenaline in isolated rat hearts?
Dietary linoleic acid alters baseline cardiac function and modifies the heart's physiological response to isoprenaline in a rat model.
Hoffmann et al. (1982) studied this question. Diet rich in linoleic acid (LA) vs. LA-deficient diet (30% hydrogenated palm kernel oil) or standard lab chow was evaluated on Cardiac function, coronary flow rate, prostaglandin release, and effects of isoprenaline. A diet rich in linoleic acid increased contractile force, coronary flow rate, and prostaglandin release, while diminishing the inotropic effects of isoprenaline in isolated rat hearts.
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