Key result
Total sleep deprivation linked to slowest working memory and weakest cerebral responses at 4:00 a.m.
Why the study?
How the dynamic interaction of circadian rhythmicity and homeostatic sleep pressure affects working memory performance and cerebral responses was not well elucidated.
Population
Thirty-six healthy subjects with intermediate chronotype
Comparison
Sternberg working-memory task and fMRI across time points (10:00 p.m., 04:00 a.m., and 06:00 a.m.)
Authors
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TSD may impair working memory performance and brain responses; hypothesis-generating for circadian-homeostatic interactions in chronobiology.
Observational (n=36)
Working memory performance and cerebral responses show a rebound after the mid-time point of regular biological sleep night during total sleep deprivation.
Zhu et al. (2019) conducted an observational in Healthy subjects (n=36). Total sleep deprivation vs. Different time points during sleep deprivation was evaluated on Sternberg working-memory task (SWMT) reaction time and cerebral responses. Total sleep deprivation resulted in the slowest working memory reaction time and weakest cerebral responses at 04:00 a.m. rather than at the end of the deprivation period at 06:00 a.m.
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