Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 2015Memórias do Instituto Oswaldo CruzOpen Access

Molecular characterisation of the NSP4 gene of group A human rotavirus G2P4 strains circulating in São Paulo, Brazil, from 1994 and 2006 to 2010

View Full Paper
Ask AI
Bookmark
Share

Key result

Rotavirus G2P[4] strains demonstrate ~98% NSP4 E2 genotype prevalence, consistent with VP4/VP7 linkage.

  • n=41

Population

41 Group A human rotavirus G2P[4] strains collected in the state of São Paulo, Brazil from 1994 and 2006-2010

Design

Preclinical

Authors

JBJéssica Wildgrube BertólMFMaria Clara Duarte FregolenteTCThabata Alessandra Ramos Caruzo

Discussion

Loading...

Member takes

Overview

Supports rotavirus genotype surveillance in Brazil; leaves open NSP4 variation effects on pathogenesis or vaccines.

Study Design

Type

Observational (n=41)

Structured PICO

P
Population
41 Group A human rotavirus G2P[4] strains collected in São Paulo, Brazil, between 1994 and 2006-2010.
E
Exposure
Reverse transcription-polymerase chain reaction, sequencing, and phylogenetic analysis of the NSP4 gene
O
Outcome
NSP4 genetic diversity and genotype distribution

Main Result

Absolute Event Rate: 97.6% vs 2.4%

The study demonstrates that most HuRVA G2P[4] strains in São Paulo belong to the E2 genotype, with variations in the C-terminal region, highlighting the importance of monitoring NSP4 variations for evaluating rotavirus circulation and pathogenesis.

Cite This Study

Bertól et al. (2015) conducted an observational in Group A human rotavirus (HuRVA) infection (n=41). NSP4 gene analysis was evaluated on NSP4 genotype distribution. Among 41 human rotavirus G2P[4] strains from São Paulo, 97.6% displayed the NSP4 E2 genotype and 2.4% displayed the E1 genotype, consistent with linkage between VP4/VP7 and NSP4 genotypes.

synapsesocial.com/papers/6aa1fe3dcfba0f0e6d07e705https://doi.org/10.1590/0074-02760150199
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serological and molecular diversity of human rotavirus in São Paulo, Brazil2007 · 13 citations
  2. 2Humoral and cell-mediated immune responses in humans to the NSP4 enterotoxin of rotavirus1999 · 60 citations
  3. 3Frequent Reassortments May Explain the Genetic Heterogeneity of Rotaviruses: Analysis of Finnish Rotavirus Strains2002 · 92 citations
  4. 4Hospital-based Surveillance to Evaluate the Impact of Rotavirus Vaccination in São Paulo, Brazil2010 · 106 citations