Key result
Ambulatory anesthesia sedative combinations produce impairment matching or exceeding ~0.11% BAC.
Why the study?
Do sedative/analgesic combinations used in ambulatory surgery produce impairment similar to alcohol in healthy volunteers?
Population
12 healthy human volunteers (10 males and 2 females; age range 21-34 yr)
Comparison
Fentanyl 50 micrograms and propofol 35 mg… vs Alcohol 56 g and placebo
Design
RCT, randomized, cross-over, double-blind
Follow-up
240 min postinjection
Authors
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Warrants stricter discharge criteria and driving restrictions after ambulatory sedation; extends RCT evidence benchmarking psychomotor impairment to alcohol levels.
RCT (n=12)
double-blind
randomized, cross-over
Do sedative/analgesic combinations used in ambulatory surgery produce impairment similar to alcohol in healthy volunteers?
Commonly used sedative/analgesic combinations in ambulatory anesthesia produce psychomotor and subjective impairment similar to or greater than a large dose of alcohol.
Thapar et al. (1995) conducted an RCT in Healthy volunteers (n=12). Sedative/analgesic combinations (fentanyl, midazolam, propofol) vs. Alcohol 56 g and placebo was evaluated on Psychomotor performance, subjective effects, and short-term memory. Sedative/analgesic combinations used in ambulatory anesthesia produced impairment similar to or greater than that observed with a large dose of alcohol (BAC 0.11%).
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