Key result
Propofol reduces time to stand steadily by ~47% versus thiopental and shortens psychomotor impairment.
Why the study?
Does propofol improve clinical recovery and psychomotor function compared to thiopental in healthy volunteers?
Population
12 healthy volunteers
Comparison
Propofol (2.5 mg/kg and 1.0 mg/kg 3 min later) vs Thiopental (5.0 mg/kg and 2.0 mg/kg 3 min later)
Design
RCT, crossover, double-blind
Follow-up
7 hours
Authors
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Propofol enables faster recovery after brief anesthesia; confirms its preference over thiopental for ambulatory procedures in healthy adults.
RCT (n=12)
Double-blind
Does propofol improve clinical recovery and psychomotor function compared to thiopental in healthy volunteers?
Absolute Event Rate: 33% vs 62%
p-value: p=<0.05
Propofol allows for significantly faster clinical recovery and return of psychomotor function compared to thiopental, making it suitable for brief ambulatory surgery.
Korttila et al. (1992) conducted an RCT in Healthy volunteers (n=12). Propofol vs. Thiopental was evaluated on Time until standing steadily (p=<0.05). Brief anesthesia with propofol resulted in significantly faster time until standing steadily (33 vs 62 minutes; P<0.05) and shorter duration of psychomotor impairment compared to thiopental.
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