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October 1, 1992Acta Anaesthesiologica Scandinavica

Thiopentone or propofol for induction of isoflurane‐based anaesthesia for ambulatory surgery?

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Why the study?

Does propofol improve psychomotor recovery compared to thiopentone for induction of isoflurane-based anaesthesia in healthy patients undergoing outpatient arthroscopic knee surgery?

Population

30 healthy, unpremedicated patients undergoing outpatient arthroscopic procedures of the knee

Comparison

Propofol 2-3 mg/kg for induction of anaesthesia… vs Thiopentone 5-6 mg/kg for induction of…

Design

RCT, randomly divided into two groups

Follow-up

120 minutes postoperatively

Authors

AGAbhinav GuptaKeck Hospital of USCLLL. E. LarsenLinköping University HospitalFSFolke SjöbergLinköping University

Discussion

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Implication

Propofol may be preferred for induction in ambulatory anesthesia; extends RCT evidence of faster psychomotor recovery versus thiopentone.

Structured PICO

Does propofol improve psychomotor recovery compared to thiopentone for induction of isoflurane-based anaesthesia in healthy patients undergoing outpatient arthroscopic knee surgery?

P
Population
30 healthy, unpremedicated patients undergoing outpatient arthroscopic procedures of the knee
I
Intervention
Propofol 2-3 mg/kg for induction of anaesthesia, maintained with isoflurane (0.5-2%) in oxygen and air, with alfentanil supplements
C
Comparator
Thiopentone 5-6 mg/kg for induction of anaesthesia, maintained with isoflurane (0.5-2%) in oxygen and air, with alfentanil supplements
O
Outcome
Psychomotor recovery assessed by perceptive accuracy test (PAT), simple reaction time (SRT), choice reaction time (CRT), and digit symbol substitution test (DSST) every 30 min postoperatively for 120 minsurrogate

Induction of anaesthesia with propofol followed by isoflurane maintenance is associated with more rapid psychomotor recovery than thiopentone in ambulatory surgery.

Limitations

  • SRT, CRT and DSST proved to be relatively insensitive in the detection of residual effects of anaesthesia and had a significant learning effect

Cite This Study

Gupta et al. (1992) studied this question.

synapsesocial.com/papers/6a8425ec84161f555bc52290https://doi.org/10.1111/j.1399-6576.1992.tb03541.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Propofol vs thiopentone as anaesthetic agents for short operative procedures1987 · 39 citations
  2. 2Comparison of Propofol with Methohexital for Outpatient Anesthesia1986 · 120 citations
  3. 3Comparison of Propofol with Methohexital for Outpatient Anesthesia1987 · 132 citations
  4. 4Anaesthesia for cardioversion — clinical experiences with propofol and thiopentone1991 · 17 citations
  5. 5Isoflurane for conscious sedation1988 · 18 citations