Key result
Propofol for general anesthesia resulted in faster recovery room discharge (67.9 vs 80.0 min, p<0.05) and lower systolic blood pressure compared to thiopental and isoflurane.
Why the study?
Does propofol improve hemodynamics and recovery time compared to thiopental and isoflurane in patients undergoing general anesthesia?
RCT (n=60)
Open-label
Randomized
Does propofol improve hemodynamics and recovery time compared to thiopental and isoflurane in patients undergoing general anesthesia?
Absolute Event Rate: 67.9% vs 80%
p-value: p=<0.05
Propofol provides safe and effective induction and maintenance of general anesthesia with faster recovery times compared to thiopental and isoflurane.
Propofol may expedite postanesthesia recovery in general anesthesia; extends RCT evidence favoring its use over thiopental-isoflurane.
Propofol, a phenol compound with a short elimination half-life, was compared with thiopental and isoflurane for induction and maintenance of general anesthesia in 60 consenting ASA I, II, and III patients. The study was randomized and open label in design. Hemodynamically, the propofol patients showed a mean +/- SEM decrease in systolic blood pressure in comparison with the thiopental/isoflurane group at 2 (115.1 +/- 4.9 vs. 136.6 +/- 6.0 mmHg), 3 (125.7 +/- 5.1 vs. 149.4 +/- 5.6 mmHg), and 5 min (126.6 +/- 3.8 vs. 144.4 +/- 6.1 mmHg) postinduction and at intubation (135.2 +/- 4.7 vs. 157.8 +/- 6.0 mmHg) (p less than 0.05). The heart rate was lower in the propofol group throughout the induction period (p less than 0.05). Patients who received propofol were ready for discharge from the recovery room sooner (67.9 +/- 4.0 vs. 80.0 +/- 3.6 min) than the thiopental/isoflurane-treated patients (p less than 0.05). Propofol is as safe and effective for induction and maintenance of general anesthesia as thiopental and isoflurane.
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Gold et al. (1989) conducted an RCT in General anesthesia (n=60). Propofol vs. Thiopental and isoflurane was evaluated on Time to discharge from the recovery room (minutes) (p=<0.05). Propofol for general anesthesia resulted in faster recovery room discharge (67.9 vs 80.0 min, p<0.05) and lower systolic blood pressure compared to thiopental and isoflurane.
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