A Comparative Study of Haemodynamic Changes and Blood Sugar Levels Before and After Induction of General Anaesthesia With Thiopentone and Propofol”

In this study a total of 100 patients of ASA I & II undergoing elective surgery under general anaesthesia were randomized in two groups comprising 50 patients each. An informed written consent was obtained from all the patients. This study is conducted at Kamineni Academy of Medical sciences and research centre,Hyderabad. Among the two groups, the first group (Group T) all the patients were induced with Inj. Thiopentone 5mg/kg body weight IV and second (Group P) patients were induced with Inj. Propofol 5mg/kg body weight IV respectively. There after random blood sugar (RBS) was recorded 5 min before induction (5 min BI). Before induction base line vital parameters were recorded; including blood pressure and heart rate. The demographic data was comparable in two groups.The results of our study showed that Propofol significantly reduced PR, SBP, DBP, MAP, and RPP after induction and 1,3,5,10 min after endotracheal intubation as compared to Thiopentone. Systolic blood pressure and diastolic arterial blood pressure and mean arterial pressure were below the baseline or near the baseline in propofol group after induction and intubation while in thiopentone group, all the values were above the baseline after induction. Heart rate was above the baseline after induction in thiopentone group while it was below the baseline in propofol group. Thus Propofol provides stable hemodynamic condition during induction, laryngoscopy and endotracheal intubation when compared to thiopentone.