Key result
Propofol (2 mg/kg) significantly attenuated the pressor response to laryngoscopy and intubation, providing more stable hemodynamics compared to thiopentone (5 mg/kg).
Why the study?
Does propofol compared to thiopentone attenuate the pressor response to induction and endotracheal intubation in patients undergoing surgery?
RCT (n=200)
Does propofol compared to thiopentone attenuate the pressor response to induction and endotracheal intubation in patients undergoing surgery?
Propofol provides more stable hemodynamic conditions and better attenuates the pressor response to laryngoscopy and intubation compared to thiopentone.
Propofol may be preferred over thiopentone for hemodynamic stability during intubation; extends RCT evidence in surgical patients.
Aims And Objectives-To quantify and compare cardiovascular response to direct laryngoscopy and endotracheal intubation using Thiopentone and Propofol.Material and Methods- 200 patients of ASA-Grade I and II between 15-60 years, of either sex scheduled for elective and emergency surgery were selected. Group A received Inj. Thiopentone sodium 5 mg/kg (2.5%) and Group B received Inj. Propofol 2 mg/kg (1%) ,100 patients in each group. Pulse rate(PR), systolic and diastolic blood pressure(SBP and DBP), mean arterial pressure(MAP) and rate-pressure product(RPP) were recorded pre and post- induction and post-intubation at 1,3 and 5 min.Results- At 1 min after laryngoscopy and intubation, PR increased significantly in both the groups. Increase was significantly more in Group A than in Group B At 3 min after intubation, Increase in PR was significantly greater in Group A than in Group B. At 5 minutes, PR decreased in both the groups, difference being statistically insignificant. SBP,DBP,MAP and RPP decreased significantly after induction and intubation at 1,3,5 min in Group B than in Group A.Conclusion - a single induction dose of propofol attenuates, but does not prevent the pressor response to laryngoscopy and intubation. Propofol provides stable hemodynamic condition during induction, laryngoscopy and endotracheal intubation when compared to thiopentone.
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Virendra Belekar (2012) conducted an RCT in Patients scheduled for elective and emergency surgery (n=200). Propofol vs. Thiopentone sodium 5 mg/kg was evaluated on Cardiovascular response (pulse rate, systolic and diastolic blood pressure, mean arterial pressure, and rate-pressure product). Propofol (2 mg/kg) significantly attenuated the pressor response to laryngoscopy and intubation, providing more stable hemodynamics compared to thiopentone (5 mg/kg).
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