Key result
Etomidate provided significantly greater hemodynamic stability during induction of general anesthesia compared to propofol, which caused a 10 mmHg decrease in mean arterial pressure (p<0.01).
Why the study?
Hemodynamic changes are inevitable during the induction of general anesthesia, prompting a comparison of the hemodynamic effects caused by thiopental, propofol, and etomidate.
Does etomidate or thiopentone improve hemodynamic stability compared to propofol during induction of general anesthesia in patients undergoing elective surgery?
RCT (n=90)
Double-blind
Randomized
No
Does etomidate or thiopentone improve hemodynamic stability compared to propofol during induction of general anesthesia in patients undergoing elective surgery?
p-value: p=<0.01
Etomidate provides better hemodynamic stability compared to propofol and thiopentone during the induction of general anesthesia.
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Clinicians should prefer etomidate or thiopentone over propofol for induction when hemodynamic stability matters; this RCT confirms their superior blood-pressure preservation.
Annapoorani et al. (2019) conducted an RCT in Elective surgery requiring general anesthesia (n=90). Etomidate vs. Propofol and Thiopentone was evaluated on Decrease in mean arterial pressure (MAP) after induction (p=<0.01). Etomidate provided significantly greater hemodynamic stability during induction of general anesthesia compared to propofol, which caused a 10 mmHg decrease in mean arterial pressure (p<0.01).
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