Key result
Chronic respiratory insufficiency is linked to ~41 ms longer P300 latency and prolonged somatosensory latencies.
Why the study?
Does chronic respiratory insufficiency affect cognitive, somatosensory, and brainstem auditory evoked potentials compared to healthy subjects?
Case-Control (n=32)
No
Does chronic respiratory insufficiency affect cognitive, somatosensory, and brainstem auditory evoked potentials compared to healthy subjects?
Absolute Event Rate: 400.1% vs 359.1%
p-value: p=0.0090
Chronic respiratory insufficiency is associated with prolonged cognitive and somatosensory evoked potentials, indicating selective vulnerability of these functions.
May indicate subclinical neurophysiological changes; hypothesis-generating for evoked potential monitoring in respiratory disease.
P300, somatosensory evoked potential (SEP) and brainstem auditory evoked potential (BAEP) are widely used neurophysiological methods for objectively evaluating cognitive, somatosensory and brainstem auditory functions. We studied the P300, SEP and BAEP in 17 patients with chronic respiratory insufficiency (PaO2:58.2 +/- 7.0 mmHg; mean +/- SD) and 15 age-matched healthy subjects (PaO2: 84.4 +/- 11.3 mmHg). The latency and amplitude of P300, the N9 latency, N9-N13 and N13-N20 interpeak latencies (IPL) in SEP, wave I latency and I-V IPL in BAEP were compared between the patients and controls. The P300 latency, N9-N13 and N13-N20 IPLs in SEP in the patients were significantly prolonged compared to the controls. In contrast, the amplitude of P300, N9 latency in SEP, wave I latency and I-V IPL in BAEP were not significantly different between the patients and controls. These results suggest that chronic respiratory insufficiency influences the cognitive and somatosensory functions, and indicate that there is a selective vulnerability of evoked potentials to this condition.
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Nakano et al. (1997) conducted a case-control in Chronic respiratory insufficiency (n=32). Chronic respiratory insufficiency vs. Healthy controls was evaluated on P300 Latency (ms) (p=0.0090). Chronic respiratory insufficiency was associated with significantly prolonged P300 latency (400.1 vs 359.1 ms, p=0.009) and somatosensory interpeak latencies compared to healthy controls.
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