Review reveals structural protein imbalances in pediatric connective tissue dysplasia, highlighting the need to investigate non-hereditary molecular mechanisms.
Pathogenesis connective tissue dysplasia (CTD) is an important pediatric issue. CTD is characterized by polymorpfism of phenotypic and visceral signs. Pathogenetic aspect connected with disbalance of collagenic and non-collagenic proteins deserve special attention when children have non-hereditary forms of CTD. The role of elastin and laminin disbalance and the genome «major proteins» that participate in tissue structures' formation remains an understudied issue.
No takes yet. Share an insight, caveat, or question.
Cherkasov et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: