What question did this study set out to answer?

To compare carboxylated graphene and mercaptopropionic acid monolayer surfaces for surface-plasmon and electrochemical immunoassay detection of serum glutamic acid decarboxylase 65 autoantibodies.

September 14, 2018Analytical Chemistry

Electrochemical and Surface-Plasmon Correlation of a Serum-Autoantibody Immunoassay with Binding Insights: Graphenyl Surface versus Mercapto-Monolayer Surface

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Authors

GPGayan PremaratneOklahoma State University Oklahoma City JNJinesh NiroulaFreenome (United States)MPManoj PatelPandit Ravishankar Shukla University

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Implication

Comparative study demonstrates superior sensitivity using carboxylated graphene over mercapto monolayers for diabetes autoantibodies, indicating improved biosensor manufacturing.

Key Points

To compare carboxylated graphene and mercaptopropionic acid monolayer surfaces for surface-plasmon and electrochemical immunoassay detection of serum glutamic acid decarboxylase 65 autoantibodies.
Fabricated surface-plasmon and electrochemical sensor surfaces modified with either carboxylated (~5.0%) graphene or mercaptopropionic acid (MPA) self-assembled monolayers.
Quantified surface carboxyl groups via covalent tagging with electroactive aminoferrocene and examined surface chemistry using X-ray photoelectron spectroscopy.
Carboxylated graphene exhibited 9-fold more carboxyl groups, larger binding affinity, higher sensitivity, and lower detection limits than the MPA monolayer surface.
Graphene-carboxyl coating on gold produced an approximately 5.5-fold enhancement of plasmon signals relative to an identical coating on plain glass.

Cite This Study

Premaratne et al. (2018) studied this question.

synapsesocial.com/papers/6aa206cdc6dcf781b3ef9d15 https://doi.org/10.1021/acs.analchem.8b01565

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Implication

Comparative study demonstrates superior sensitivity using carboxylated graphene over mercapto monolayers for diabetes autoantibodies, indicating improved biosensor manufacturing.

Electrochemical and Surface-Plasmon Correlation of a Serum-Autoantibody Immunoassay with Binding Insights: Graphenyl Surface versus Mercapto-Monolayer Surface

Discussion

Member takes

Implication

Key Points

Cite This Study

Electrochemical and Surface-Plasmon Correlation of a Serum-Autoantibody Immunoassay with Binding Insights: Graphenyl Surface versus Mercapto-Monolayer Surface

Discussion

Member takes

Implication

Key Points

Cite This Study

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