Key result
High-sensitivity troponin T (OR 2.153) and CK-MB (OR 1.138) significantly predicted cardiovascular risk in asymptomatic end-stage renal disease patients, with their combination yielding the highest diagnostic accuracy (AUC 0.920).
Why the study?
Does the combined use of hs-TnT and CK-MB improve the prediction of cardiovascular events in asymptomatic ESRD patients on hemodialysis compared to either marker alone?
Case-Control (n=110)
No
Does the combined use of hs-TnT and CK-MB improve the prediction of cardiovascular events in asymptomatic ESRD patients on hemodialysis compared to either marker alone?
Answers are grounded in this paper and cite their sources.
The combination of hs-TnT and CK-MB provides high diagnostic accuracy (AUC 0.920) for predicting cardiovascular events in asymptomatic patients with end-stage renal disease on hemodialysis.
BACKGROUND: The principal goal of this study was to determine the importance of high-sensitivity troponin T (hs-TnT) and creatine kinase MB isoenzyme (CK-MB) in predicting cardiovascular events in asymptomatic end-stage renal disease (ESRD) patients. METHODS: This study included 110 participants; 54 ESRD patients undergoing hemodialysis and 56 healthy control participants. Biochemical parameters and cardiac markers were estimated. Comparative utilities were assessed through logistic regression and receiver operating characteristic (ROC) analyses. The diagnostic performance of hs-TnT and CK-MB alone and the combination of the two biomarkers was assessed by the area under the ROC curve (AUC). The highest AUC was produced by the combination of hs-TnT and CK-MB markers (0.920) compared to hs-TnT or CK-MB alone. CONCLUSION: In asymptomatic patients with ESRD, hs-TnT appeared to be an important predictor for cardiovascular mortality, and its diagnostic accuracy improved with CK-MB. This study provides new insights into the predictive value of multiple biomarkers for identifying cardiovascular events in ESRD patients on hemodialysis.
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Ahmed et al. (2017) conducted a case-control in End-stage renal disease (n=110). High-sensitivity troponin T and creatine kinase MB isoenzyme vs. Healthy controls was evaluated on Prediction of cardiovascular events (OR 2.153, 95% CI 1.336-2.961, p=0.017). High-sensitivity troponin T (OR 2.153) and CK-MB (OR 1.138) significantly predicted cardiovascular risk in asymptomatic end-stage renal disease patients, with their combination yielding the highest diagnostic accuracy (AUC 0.920).
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