Key result
Dextran 40 in cardioplegia yields higher colloid oncotic pressure during and after CPB vs crystalloid.
Why the study?
Does the addition of dextran 40 to cardioplegic solution affect colloid oncotic pressure in patients undergoing open-heart surgery for coronary artery disease?
Does the addition of dextran 40 to cardioplegic solution affect colloid oncotic pressure in patients undergoing open-heart surgery for coronary artery disease?
Adding dextran 40 to cardioplegia increases colloid oncotic pressure during and immediately after cardiopulmonary bypass without affecting hemodynamics or clinical outcomes.
Answers are grounded in this paper and cite their sources.
Should not alter cardioplegia practice; leaves open whether higher oncotic pressure improves outcomes in randomized trials.
Thirty-one patients undergoing open-heart surgery for uncomplicated coronary artery disease were studied. All patients had dextran 70 (Macrodex, Pharmacia) in the priming solution. In Group I patients (n = 16) 3.5% dextran 40 (Rheomacrodex, Pharmacia) was added to the cardioplegic solution. Group II patients (n = 15) received our standard crystalloid cardioplegia. A higher colloid oncotic pressure (COP) was noticed in Group I during cardiopulmonary bypass (CPB) and immediately postoperatively. The albumin levels were higher in Group II during and after bypass. No differences could be demonstrated in the concentrations of total serum protein. Preoperative levels of COP were reached two hours postoperatively and 24 hours postoperatively for albumin and total proteins. The addition of dextran 40 to the cardioplegic solution did not influence haemodynamic parameters. The clinical course was uneventful in both groups.
No takes yet. Share an insight, caveat, or question.
Lindberg et al. (1988) studied Uncomplicated coronary artery disease (n=31). 3.5% dextran 40 added to cardioplegic solution vs. Standard crystalloid cardioplegia was evaluated on Colloid oncotic pressure (COP) during and after cardiopulmonary bypass. Adding 3.5% dextran 40 to the cardioplegic solution resulted in higher colloid oncotic pressure during and immediately after cardiopulmonary bypass compared to standard crystalloid cardioplegia.
Synapse has enriched 10 related papers. Consider them for comparative context: