Key result
Recent MI links to increased pericardial inflammation, and murine pericardial removal causes ~50% rupture mortality.
Why the study?
The pericardium contains fat-associated lymphoid clusters, but its immune functions have been widely overlooked.
Does the pericardium promote cardiac repair and remodelling post-myocardial infarction?
Population
Patients with stable CAD, patients with recent MI, and a murine MI model
Comparison
Pericardium removal prior to MI vs intact pericardia in mice; recent MI vs stable CAD in patients
Design
Translational patient study and murine experimental model
Authors
Loading...
Pericardial preservation may avert post-MI rupture; leaves open whether targeting its inflammation improves human remodeling.
Observational (n=73)
Does the pericardium promote cardiac repair and remodelling post-myocardial infarction?
Absolute Event Rate: 1.35% vs 0.8%
p-value: p=0.0001
The pericardium plays a crucial role in regulating inflammation, macrophage polarisation, and tissue remodelling following myocardial infarction, preventing cardiac rupture.
Mylonas et al. (2019) conducted an observational in Coronary artery disease (n=73). Recent myocardial infarction vs. Stable coronary artery disease was evaluated on Maximum tissue-to-background ratio (TBRmax) of pericardial 18F-FDG uptake (p=0.0001). Recent myocardial infarction increased pericardial inflammation in patients (TBRmax 1.35 vs 0.80), and murine models showed pericardium removal prior to MI caused 50% mortality from cardiac rupture.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: