Key result
Mitochondrial impairment drives diabetic cardiomyopathy pathogenesis through oxidative stress, energy dysfunction, and calcium imbalance.
Why the study?
The detailed pathogenesis of diabetic cardiomyopathy remains unclear, although evidence suggests mitochondrial structural and functional impairment plays an integral role.
Mitochondrial dysfunction is a central mechanism in the pathogenesis of diabetic cardiomyopathy, presenting a promising therapeutic target for future treatments.
May support mitochondrial-targeted therapies in diabetic cardiomyopathy; leaves open translation from animal models to patients.
Cardiovascular complication is one of the significant causes of death in diabetic mellitus (DM) in which diabetic cardiomyopathy, independent of hypertension, cardiac valvular disease, and coronary atherosclerosis, occupies an important position. Although the detailed pathogenesis of diabetic cardiomyopathy remains unclear currently, mitochondrial morphological abnormality and dysfunction were observed in diabetic cardiomyopathy animal models according to much research, suggesting that mitochondrial structural and functional impairment played an integral role in the formation of diabetic cardiomyopathy. Thus, we have summarized the effect of mitochondria on the process of diabetic cardiomyopathy, including abnormal mitochondrial morphology, mitochondrial energy metabolism disorder, enhanced mitochondrial oxidative stress, mitochondrial unbalanced calcium homeostasis, and mitochondrial autophagy. Based on the above mechanisms and the related evidence, more therapeutic strategies targeting mitochondria in diabetic cardiomyopathy have been and will be proposed to delay the progression of the disease.
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Bai et al. (2021) conducted a review in Diabetic Cardiomyopathy. Mitochondria-targeted therapies was evaluated. Mitochondrial impairment, including abnormal morphology, energy metabolism disorder, oxidative stress, and unbalanced calcium homeostasis, plays a critical role in the pathogenesis of diabetic cardiomyopathy.
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