PINEALECTOMY in the immature rat causes statistically significant increases in gonadal weight (Izawa, 1926; Kitay, 1954; Simonnet et al., 1951). On the other hand, the administration of pineal extract in the rat is said to produce either gonadal hypertrophy (Milco, 1941), gonadal atrophy (Engel, 1934; Moszkowska, 1951; Tsuchimoto, 1933; Wakida, 1944), or no change in gonadal weight (Hartog Jager and Heil, 1935; Hoskins, 1916; Roux, 1937; Sisson and Finney, 1920; Tomorug and Hussar, 1942; Waysbaum- Moschkowski, 1945). The last finding has been generally accepted despite the fact that all of the published data on pineal extract administration in the rat are fragmentary and inconclusive. In view of this lack of statistically significant data, the following preliminary study was undertaken. MATERIAL AND METHODS Powdered bovine pineal glands were supplied by the Wilson Laboratories of Chicago, Illinois. The glands, obtained from two-year-old government-inspected steers, had been removed and frozen shortly afte...
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Kitay et al. (1954) studied this question.