Atractylodes macrocephala Koidz is a traditional medicinal plant in China and is known for the treatment of gastroenteric and splenic disorders. The EtOAc extract of A. macrocephala was chromatographed to give a novel bisesquiterpenoid, biatractylolide ( 1 ). The structure of 1 was determined by spectroscopic methods, mainly 2D-NMR techniques.
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Lin et al. (1997) studied this question.
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