Key result
Dysregulated vascular factors like VEGF-A and angiopoietins offer novel therapeutic targets for diabetic kidney disease.
Design
Review
Authors
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Extends mechanistic understanding of diabetic glomerulopathy; leaves open whether targeting VEGF-A or angiopoietins improves clinical outcomes.
Endothelial dysfunction is implicated as a major mechanism for renal chronic microvascular complications, contributing to the progression of diabetic kidney disease and associated cardiovascular risk.
Karalliedde et al. (2011) conducted a review in Diabetic nephropathy. Endothelial factors (VEGF-A, Angiopoietins, Adiponectin) was evaluated. Dysregulation of vascular factors such as VEGF-A and angiopoietins plays a crucial role in diabetic glomerulopathy and may offer novel therapeutic targets for diabetic kidney disease.
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