Key result
Higher baseline hemoglobin levels were independently associated with better estimated glomerular filtration rate in patients with type 2 diabetes mellitus (β 0.48).
Why the study?
To examine the relationship between hemoglobin levels and estimated glomerular filtration rate in patients with type 2 diabetes mellitus.
Is baseline hemoglobin level associated with estimated glomerular filtration rate in patients with type 2 diabetes mellitus and diabetic kidney disease?
Cross-Sectional (n=123)
No
Is baseline hemoglobin level associated with estimated glomerular filtration rate in patients with type 2 diabetes mellitus and diabetic kidney disease?
Baseline hemoglobin level is independently and positively associated with baseline eGFR in patients with type 2 diabetes mellitus and diabetic kidney disease.
Aims: We examined the relationship between the hemoglobin (Hb) level and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). Methods:This cross-sectional study recruited a total of 139 patients with T2DM and diabetic kidney diseases.Various demographic and clinical characteristics at baseline (age, sex, BMI, duration of diabetes, systolic/diastolic blood pressure, Fasting blood glucose, HbA1c, serum albumin, Uric acid, Triglyceride, Total cholesterol, LDL-C, 24-h protein excretion, serum creatinine, eGFR and antidiabetic therapy) were examined.The relationship between hemoglobin (Hb) level and eGFR was examined by Pearson's correlation analyses.Multivariate regression analyses were used to assess the association of hemoglobin (Hb) level with eGFR.Results: A positive correlation was found between hemoglobin and eGFR (r =0.1564, p<0.0001);A negative correlation was found between hemoglobin and Serum creatinine (r =-0.1613, p<0.0001).The baseline hemoglobin (Hb) level and baseline eGFR have liner relationship.Multivariate regression analyses showed that eGFR was associated with hemoglobin, estimates β(CI) was 0.45 (0.21, 0.68), 0.41 (0.18, 0.63), 0.48 (0.16, 0.79) in Non-adjusted, Multivariate-Adjust Model I and Multivariate-Adjust Model II, respectively. Conclusions:The hemoglobin level at baseline is an independent protective factor of baseline eGFR, and monitoring of hemoglobin can play an important role in management of diabetic nephropathy.
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Qijun Wan (2022) conducted a cross-sectional in Type 2 Diabetes Mellitus and Diabetic Kidney Disease (n=123). Baseline hemoglobin level was evaluated on Estimated glomerular filtration rate (eGFR) (β 0.48, 95% CI 0.16-0.79, p=0.004). Higher baseline hemoglobin levels were independently associated with better estimated glomerular filtration rate in patients with type 2 diabetes mellitus (β 0.48).
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