The Relationship of Glycated Albumin Levels and Estimated Glomerular Filtration Rate (eGFR) in Patients with Type 2 Diabetes Mellitus

Diabetes Mellitus (DM) is a chronic condition associated with increased blood glucose levels exceeding the normal limit. Type 2 Diabetes Mellitus (T2DM) is the most frequent type of DM. Glycaemic status control in DM patients can prevent complications of DM, for instance measuring glycated albumin (GA) levels. A decline in renal function is one of the most often complications due to DM. In clinical practice, renal function decline can be evaluated by estimated glomerular filtration rate (eGFR) formulas, such as Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Aim: To analyze the association between GA levels and eGFR calculated with CG, MDRD, and CKD-EPI formula in patients with T2DM. Methods: This study was an observational analytical study with a cross-sectional design conducted on 67 subjects from February – October 2021. The data obtained for this research was secondary data from the medical records of T2DM patients at Diponegoro National Hospital. The independent variable in this research was GA levels and the dependent variable was eGFR. The correlation analysis was done using Pearson test. Results: The Pearson’s correlation test results between GA levels and eGFR calculated with CG, MDRD, and CKD-EPI formula in patients with type 2 DM were p=0,081and r=0,215; p=0,060 and r=0,231; p=0,062 and r=0,229, respectively. Conclusion: There was no significant association between GA levels and eGFR in patients with type 2 DM.