The phase problem is reduced to a sign problem once the anomalous-scatterer or the replacing-heavy-atom sites are located.OASISadopts theCCP4 format [Collaborative Computational Project, Number 4 (1994).Acta Cryst.D50, 760–763]. It applies a direct-method procedure to break the phase ambiguity intrinsic to one-wavelength anomalous scattering (OAS) or single isomorphous replacement (SIR) data.
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Hao et al. (2000) studied this question.
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