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October 1, 1978ThoraxOpen Access

Valve replacement for rheumatic aortic incompetence in adolescents.

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Key result

AVR for adolescent rheumatic AR shows 0 operative deaths and symptom relief but frequent myocardial damage.

  • n=20

Why the study?

Does aortic valve replacement improve haemodynamic recovery and symptoms safely in adolescents with rheumatic aortic incompetence?

Population

20 adolescent patients with rheumatic aortic incompetence (regurgitation), mean age 15 years.

Design

Case_series

Authors

ΕWΕ. Kenneth WeirUniversity of MinnesotaRMRodney E. MatisonnWentworth HospitalAMA S MithaUniversity of Minnesota

Discussion

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Implication

Improves symptoms without operative mortality in adolescent rheumatic AR but with high myocardial damage; leaves open safer myocardial protection strategies.

Study Design

Type

Observational (n=20)

Structured PICO

Does aortic valve replacement improve haemodynamic recovery and symptoms safely in adolescents with rheumatic aortic incompetence?

P
Population
20 adolescents (mean age 15 years) with rheumatic aortic regurgitation who underwent aortic valve replacement.
E
Exposure
Aortic valve replacement
O
Outcome
Haemodynamic recovery (symptoms, cardiothoracic ratio, left ventricular hypertrophy on ECG, left ventricular end-diastolic pressure, ejection fraction) and risks of operation (mortality and morbidity)

While aortic valve replacement in adolescents with rheumatic aortic regurgitation improves symptoms and hemodynamics, it is associated with a concerningly high incidence of perioperative myocardial damage.

Limitations

  • High incidence of serious morbidity in terms of myocardial damage at or after operation.

Cite This Study

Weir et al. (1978) conducted an observational in Rheumatic aortic regurgitation (n=20). Aortic valve replacement was evaluated on Haemodynamic recovery and operative risks (symptoms, cardiothoracic ratio, mortality, and morbidity). Aortic valve replacement in 20 adolescents with rheumatic aortic regurgitation improved symptoms in all cases with 0 operative deaths, but had a high incidence of myocardial damage.

synapsesocial.com/papers/6aa21a040c07007fbcb2b341https://doi.org/10.1136/thx.33.5.608
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The natural history of rheumatic aortic regurgitation and the indications for surgery.1976 · 54 citations
  2. 2Indices Predicting Long-term Survival after Valve Replacement in Patients with Aortic Regurgitation and Patients with Aortic Stenosis1974 · 113 citations
  3. 3MITRAL VALVOTOMY IN YOUNG PATIENTS1964 · 65 citations
  4. 4Natural History of Mitral Stenosis: A Review1972 · 298 citations
  5. 5Left Ventricular Performance Following Correction of Free Aortic Regurgitation1970 · 193 citations