Incident coronary heart disease, residual risk and traditional cardiovascular risk factors in the community: The role of the lipid-inflammatory axis

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary heart disease (n=63740). Intervention: Elevated hsCRP, Lp(a), or TGs vs. Lower levels of hsCRP, Lp(a), or TGs. Primary outcome: Incident coronary heart disease.

Natalie Arnold; Christina Magnussen; Jessica Weimann; Alina Goßling; Fabian J. Brunner; Maurizio Ferrario; Paolo Brambilla; Giancarlo Cesana; Valerio Leoni; Luigi Palmieri; Chiara Donfrancesco; Teresa Padró; Jonas Andersson; Pekka Jousilahti; Francisco Ojeda; Tanja Zeller; Allan Linneberg; Stefan Söderberg; Licia Iacoviello; Francesco Gianfagna; Susana Sans; Giovanni Veronesi; Barbara Thorand; Annette Peters; Hugh Tunstall-Pedoe; Frank Kee; Veikko Salomaa; Renate B. Schnabel; Kari Kuulasmaa; Stefan Blankenberg; Raphael Twerenbold; Wolfgang Köenig

doi:10.1016/j.ajpc.2026.101812

Why the study?

Do combinations of high hsCRP, Lp(a), or TGs modulate relative and absolute incident CHD risk within a low-risk population?

Study Design

Type

Cohort (n=63,740)

Structured PICO

Do combinations of high hsCRP, Lp(a), or TGs modulate relative and absolute incident CHD risk within a low-risk population?

P

Population

63,740 individuals free of CHD at baseline, stratified by cardiovascular risk factor burden to assess the role of the lipid-inflammatory axis.

E

Exposure

High levels of biomarkers: hsCRP (≥2 mg/L), Lp(a) (≥90th percentile), or TGs (≥150 mg/dL)

C

Comparator

Low levels of biomarkers: hsCRP (<2 mg/L), Lp(a) (<90th percentile), or TGs (<150 mg/dL)

O

Outcome

Incident coronary heart disease (CHD)hard clinical

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Cite This Study

Arnold et al. (2026) conducted a cohort in Coronary heart disease (n=63,740). Elevated hsCRP, Lp(a), or TGs vs. Lower levels of hsCRP, Lp(a), or TGs was evaluated on Incident coronary heart disease.

synapsesocial.com/papers/6aa21a071200e6cee580d1ef https://doi.org/10.1016/j.ajpc.2026.101812

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Incident coronary heart disease, residual risk and traditional cardiovascular risk factors in the community: The role of the lipid-inflammatory axis

Study Design

Structured PICO

Ask about this paper

Abstract

Discussion

Cite This Study

Incident coronary heart disease, residual risk and traditional cardiovascular risk factors in the community: The role of the lipid-inflammatory axis

Study Design

Structured PICO

Ask about this paper

Abstract

Discussion

Cite This Study

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