cation of prostaglandin E2 in various vehicles.Our own work involving over 500 patients who had a single insertion of 4 mg or 5 mg of PGE2 tablets (Prostin, Upjohn Limited) vaginally showed that about 70O0 of patients went into labour without any other intervention.'These results, like those reported recently by Mr J H Shepherd and others (14 July, p 108), are not ideal and can be improved on by seeking the optimum dose regimen, as well as the best vehicle for release of PGE2 from the many available.Until these points are established it is too soon to claim that we have the best alternative to intravenous oxitocin.
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Ratcliffe et al. (1979) studied this question.
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