Key result
Systolic HF is linked to altered systolic time intervals that correlate with NYHA class and LVEF.
Why the study?
Does the use of an electronic stethoscope to measure systolic time intervals detect abnormalities in patients with systolic heart failure compared to normal subjects?
Observational (n=115)
Does the use of an electronic stethoscope to measure systolic time intervals detect abnormalities in patients with systolic heart failure compared to normal subjects?
Electronic stethoscope measurement of systolic time intervals reveals significant abnormalities in systolic heart failure that correlate with clinical severity and ejection fraction.
May support electronic stethoscope systolic time intervals for HF detection; hypothesis-generating and requires prospective validation before practice change.
We studied the systolic time intervals, using the electronic stethoscope in 55 patients with systolic heart failure and 60 normal subjects. The measured systolic intervals were: QS1 (onset of the QRS to first heart sound S1), S1S2 (cardiologic systole: S1 to S2), QS2 (electromechanical systole: onset of the QRS to S2), CSI (cardiologic systole index: ratio of the observed S1S2 to a predicted S1S2, adjusted by heart rate), ESI (electromechanical systole index: ratio of the observed QS2 /predicted QS2) and QS1/S1S2 index. In the heart failure we observed relevant prolongation of the QS1, reduction of the CSI and increase in the QS1/S1S2. In the HF with QRS ≥ 120 ms (n=23), the QS1 and ESI were augmented in relation to HF with QRS< 120 ms. There were correlations between these alterations in CSI and QS1/S1S2 and the NYHA class and between the QS1/S1S2 and the ejection fraction by echocardiogram.
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A 2008 study conducted an observational in Systolic heart failure (n=115). Systolic heart failure vs. Normal subjects was evaluated on Systolic time intervals (QS1, S1S2, QS2, CSI, ESI, QS1/S1S2 index). Systolic heart failure was associated with prolongation of QS1, reduction of CSI, and increase in QS1/S1S2 compared to normal subjects, which correlated with NYHA class and ejection fraction.
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