Key result
Ischemic heart failure is linked to a ~103% higher PEP/LVET ratio versus healthy controls.
Why the study?
Systolic time intervals are sensitive and easy to measure parameters that may help study LV systolic dysfunction in ischemic heart disease patients with clinical heart failure compared to controls.
Do systolic time intervals measured by pulsed-Doppler echocardiography differ between patients with ischemic heart disease and clinical heart failure compared to healthy controls?
Case-Control (n=65)
Do systolic time intervals measured by pulsed-Doppler echocardiography differ between patients with ischemic heart disease and clinical heart failure compared to healthy controls?
Absolute Event Rate: 0.63% vs 0.31%
p-value: p=<0.00001
Systolic time intervals measured by pulsed-Doppler echocardiography are significantly altered in patients with ischemic heart disease and heart failure, serving as potential indicators of LV systolic dysfunction.
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Elevated PEP/LVET may mark systolic dysfunction in ischemic HF; leaves open validation as a noninvasive marker.
Seetharam et al. (2022) conducted a case-control in Ischemic heart disease with clinical heart failure (n=65). Ischemic heart disease with clinical heart failure vs. Healthy subjects without clinically established LV dysfunction was evaluated on PEP/LVET ratio (p=<0.00001). Ischemic heart disease with clinical heart failure was associated with a significantly higher PEP/LVET ratio compared to healthy controls (0.63 vs. 0.31, P<0.00001).
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