Key result
Acute myocardial infarction was associated with significant differences in left ventricular ejection time and preejection period compared to controls on the 3rd, 4th, and 7th days (p<0.001).
Why the study?
Do systolic time intervals differ between patients with acute myocardial infarction and those with chest pain but no AMI?
Observational (n=123)
Do systolic time intervals differ between patients with acute myocardial infarction and those with chest pain but no AMI?
p-value: p=<0.001
Systolic time intervals show significant dynamic changes in the early phase of acute myocardial infarction, reflecting reduced left ventricular performance, though they do not separate clinical groups with heart failure of different severity.
May signal early LV impairment post-AMI; leaves open incremental value over imaging in this observational cohort.
Systolic time intervals (STI) have been measured in 50 individuals without heart disease. Electromechanical systole (QS2), left ventricular ejection time (LVET) and preejection period (PEP), but not PEP/LVET, were correlated to heart rate (HR). Regression equations were made and used when correcting STI for HR in two groups of patients: a) 51 patients with acute myocardial infarction (AMI) b) 22 patients with chest pains, but no AMI. STI was measured on the first 4 days, on the 7th day, on the day of discharge and at a control about 60 days later. In the AMI group there was a reduction in left ventricular performance from the 1st to the 4th day, and the difference in shortening of LVET was significant (p less than 0.001), while PEP and PEP/LVET increased from the 1st to the 3rd day (p less than 0.001). Between the AMI and the control groups there were significant differences (p less than 0.001) in LVET and PEP/LVET on the 3rd, 4th and 7th day, and in PEP on the 3rd and 4th day. STI was not found to separate clinical groups with heart failure of different severity. The survivors had a lower (p less than 0.05) PEP/LVET on the 1st day than those who died. The various localization of the infarction made no difference in STI. LVET was found to be strongly correlated (p less than 0.001) to the hydroxybutyric dehydrogenase values.
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Brubakk et al. (1976) conducted an observational in Acute Myocardial Infarction (n=123). Acute myocardial infarction vs. Chest pain without AMI and healthy controls was evaluated on Systolic time intervals (LVET, PEP, PEP/LVET) (p=<0.001). Acute myocardial infarction was associated with significant differences in left ventricular ejection time and preejection period compared to controls on the 3rd, 4th, and 7th days (p<0.001).
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