Key result
Ejection fraction strongly correlated with infarct size and heart failure post-MI, while systolic time intervals showed poor correlation with ejection fraction (highest r=0.55 for PEP/LVET).
Why the study?
Do systolic time intervals and ejection fraction correlate with clinical parameters of left ventricular heart failure and infarct size in patients with acute myocardial infarction?
Observational (n=54)
Do systolic time intervals and ejection fraction correlate with clinical parameters of left ventricular heart failure and infarct size in patients with acute myocardial infarction?
Effect estimate: r=0.55
Ejection fraction determined by radionuclide technique is a better indicator of left ventricular heart failure and infarct size than systolic time intervals following acute myocardial infarction.
Supports preferring EF over systolic time intervals for post-MI LV assessment; leaves open validation against modern imaging in contemporary cohorts.
Left ventricular performance in 54 patients with acute myocardial infarction was studied by means of systolic time intervals (STI) and ejection fraction (EF) determined using radionuclide technique. The data were correlated to clinical parameters of left ventricular heart failure and size of infarction. Thirty-seven patients were studied in the convalescent period with repeated registrations at 6, 10 and 24 weeks. Patients with left ventricular heart failure had markedly depressed EF, significantly different from EF in the non-heart failure group. STI did not show any difference. A strong correlation between infarct size and EF could be demonstrated. STI discriminated significantly transmural from non-transmural infarctions, and presented significant differences between those with normal EF (greater than 50%) and patients with EF below 35%. No significant changes could be found in left ventricular performance during the convalescent period, except for an increase in corrected preejection period (PEPc) probably due to drugs. The correlation between EF and STI was poor, the highest correlation coefficient being 0.55 between EF and the ratio PEP/LVET.
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Mangschau et al. (1984) conducted an observational in Acute myocardial infarction (n=54). Systolic time intervals and ejection fraction assessment was evaluated on Correlation of left ventricular performance with clinical parameters of heart failure and infarct size (r=0.55). Ejection fraction strongly correlated with infarct size and heart failure post-MI, while systolic time intervals showed poor correlation with ejection fraction (highest r=0.55 for PEP/LVET).
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