Whoa man! Unexpected protein O-mannosylation pathways in mammals

The recent expansion of well-characterized O -mannosylated mammalian proteins beyond the archetypical example of α-dystroglycan has inspired new interest in the possibility of additional functional roles of this modification. In an effort to explore those roles, a new study now serendipitously uncovers the existence of an alternative pathway to the well-described POMT (protein O -mannosyltransferase) family of O -mannosyltransferases.